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Projects (1862)
Researchers (8611)
Units (3252)
Events (1)
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Oral Off-patent Oncology Drugs for Kids
Project leader:
Karine Buffard
Period:
9/1/08
-
8/31/11
There is an urgent need for appropriate oral formulations of anticancer drugs for the treatment of paediatric malignancies in children. The goal of the O3K consortium is to develop oral liquid formulations of Cyclophosphamide and Temozolomide, important chemotherapeutics which have been identified ...
Microfluidic electrochemical probes for both stimulation of single neuronal cells and real-time detection of inflammatory signalling compounds released from the cell.
Project leader:
Christophe Marquette
Period:
6/1/08
-
11/30/10
Modern society, because of population ageing, suffers from a growing socio-economical impact of neurodegenerative diseases such as Alzheimer's, Parkinson's and Creutzfeldt-Jakob. Despite intense research efforts, the mechanisms responsible for the onset of these neuroinflammatory events, leading to ...
Molecular imaging analysis of the function of the cytoskeletal regulator DOCK2 during physiological T cell activation
Project leader:
Britta Engelhardt
Period:
3/1/11
-
2/28/14
Recent experiments using twophoton microscopy (2PM) of lymphocytes interacting with dendritic cells (DCs) loaded with cognate peptide ? major histocompability complexes (pMHC) have uncovered their dynamic interactions inside lymphoid tissue of small rodents. Depending on the amount of pMHC on the ...
Impact of IL-7 and IFNa on nTreg development
Project leader:
Remi Cheynier
Period:
2/1/11
-
1/31/13
In developed countries, most HIV-infected patients are under highly active antiretroviral therapy (HAART). However, despite controlled viral replication, the immune reconstitution often remains incomplete, probably due to a poor reconstitution of thymic production. Apart its role in educating a ...
Molecular and structural analysis of A20 in the modulation of apoptosis: anti-inflammatory potential in vasculitis
Project leader:
Veronique Witko-Sarsat
Period:
4/1/08
-
3/31/12
The ubiquitin editing protein A20, a novel 90kDa zinc-finger protein has an universal anti-inflammatory activity by inhibiting NF-kappaB activation. In endothelial cells, the induction of A20 by inflammatory stimuli renders cells resistant to apoptosis. However, A20 can have pro-apoptotic ...
The role of A20 in dendritic cells and mast cells in the allergic immune response
Project leader:
Rudi Beyaert
Period:
3/1/09
-
2/28/11
Asthma is a chronic inflammatory airway disease in which the transcription factor NF-kB plays a crucial role. NF-kB controls the activation of mast cells and dendritic cells (DC) that contribute to disease pathogenesis. Activation of NF-kB is tightly regulated by ubiquitination and deubiquitination ...
Adrenal Androgens
Project leader:
Wiebke Arlt
Period:
2/18/08
-
2/17/10
The differentiation of male and female phenotype is established at 7-12 weeks post conceptionem. During this period, maintaining the appropiate intrauterine hormone environment is essential. In contrast to other species, the regulation of human sexual differentiation is linked with the development ...
Mechanistic insights into protein degradation by Lon, a AAA+ protease
Project leader:
Eyal Gur
Period:
4/1/10
-
3/31/14
Background: AAA+ proteases are ubiquitous molecular machines that execute regulated protein degradation in cells. Their activity is necessary for regulation of many cellular processes, as well as to clear the cell of misfolded, potentially harmful proteins. Failure to combat protein unfolding in ...
Effective Environmental Strategies for the Prevention of Alcohol Abuse among Adolescents in Europe
Project leader:
Majone Steketee
Period:
1/1/10
-
12/31/12
The consumption of alcohol among young people in Europe is rising the last years. Several studies indicate that one quarter to one third of all the students has been drinking alcohol during the last month. Also the problematic drinking is a growing issue. Especially in the age group 12 until 14 ...
DNA damage response and genome stability: The role of ATM, ATR and the Mre11 complex
Project leader:
Louisa Jacobs
Period:
7/1/08
-
6/30/13
Chromosomal DNA is continuously subjected to exogenous and endogenous damaging insults. In the presence of DNA damage cells activate a multi-faceted checkpoint response that delays cell cycle progression and promotes DNA repair. Failures in this response lead to genomic instability, the main ...
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