MID-FRAIL-STUDY -
A RANDOMIZED CLINICAL TRIAL TO EVALUATE THE EFFECTIVENESS OF A MULTI-MODAL INTERVENTION IN OLDER PEOPLE WITH TYPE 2 DIABETES ON FRAILTY AND QUALITY OF LIFE: THE MID-FRAIL STUDY 
Scientific coordinator:
N.
N.
()
Period: 2012-03-01 - 2016-02-29
The prevalence of diabetes in people ≥ 65 years approaches 25% (40% of all patients with diabetes are > 65 years). This number will increase 4-fold in people > 70 years in 2050. Diabetes results in a high personal and social health burden, and a significant public health burden in terms of rising ... |
EUROHYP-1 -
European multicentre, randomised, phase III clinical trial of hypothermia plus best medical treatment versus best medical treatment alone for acute ischaemic stroke
Scientific coordinator:
Stefan
Schwab
()
Period: 2012-02-01 - 2017-01-31
The consortium led by UKER and EuroHYP, the European Stroke Research Network for Hypothermia, proposes a large, multicentre clinical trial which will assess mild hypothermia as a novel treatment for ischemic stroke. Stroke is the second cause of death world-wide and the second cause of lost ... |
GIFTS -
Genomic and lifestyle predictors of foetal outcome relevant to diabetes and obesity and their relevance to prevention strategies in South Asian peoples.
Scientific coordinator:
Graham Alec
Hitman
()
Period: 2012-02-01 - 2015-01-31
Despite a strong genetic component to diabetes and obesity, the rapidly rising prevalence of these disorders is due to adaptation to a changing environment. The epicentre of the ‘diabetes epidemic’ is in South Asia and this is reflected in the migrant populations in Europe. Current prevention ... |
IMMOMEC -
IMmune MOdulating strategies for treatment of MErkel cell Carcinoma
Scientific coordinator:
Juergen
Becker
()
Period: 2012-01-01 - 2015-12-31
Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer of the skin associated with the recently discovered, common Merkel cell polyomavirus (MCV). With an incidence of 0.44 per 100,000 MCC is a very rare cancer. Notably, however, although MCC is 40 times less common ... |
OPTATIO -
OPtimizing TArgets and Therapeutics In high risk and refractOry Multiple Myeloma
Scientific coordinator:
Wolfgang
Willenbacher
()
Period: 2012-01-01 - 2014-12-31
Multiple Myeloma (MM) is an incurable disease with rapidly growing prevalence and poor prognosis. Consequently, it is the goal of the OPTATIO consortium to seek out novel strategies for the development of novel diagnostic and therapeutic options. The MM pathogenesis involves not only genetic ... |
RODAM -
Type 2 diabetes and obesity among sub-Saharan African native and migrant populations: dissection of environment and endogenous predisposition
Scientific coordinator:
Karien
Stronks
()
Period: 2012-01-01 - 2014-12-31
Migration from Sub-Saharan Africa (SSA) to Europe is increasing. The limited evidence suggests that the risk of type 2 diabetes (T2D) and obesity among SSA migrants is higher than among their SSA peers living in Africa and European host populations. The reasons for these observations are only ... |
E-PREDICE -
Early Prevention of Diabetes Complications in people with Hyperglycaemia in Europe
Scientific coordinator:
Jaakko
Tuomilehto
()
Period: 2012-01-01 - 2016-12-31
The current approach of T2D treatment only uses the most efficacious agents after the failure of the less effective ones. Aims: to investigate the efficacy of an early, intensive and multifactorial treatment for the prevention of diabetic complications in people with hyperglycemia currently under ... |
OCTIPS -
Ovarian Cancer Therapy – Innovative Models Prolong Survival
Scientific coordinator:
Dan
Cacsire Castillo-Tong
()
Period: 2012-01-01 - 2015-12-31
About 75% of advanced epithelial ovarian cancer (EOC) patients respond to first-line surgery and chemotherapy but most relapse and ultimately acquire platinum resistance which soon leads to death. Relapsed high grade serous ovarian cancer (HGSOC) is the single main cause of EOC-related morbidity ... |
MEDIGENE -
Genetic and environmental factors of insulin resistance syndrome and its long-term complications in immigrant Mediterranean populations
Scientific coordinator:
Florin
Grigorescu
()
Period: 2012-01-01 - 2015-12-31
MEDIGENE project will study genetic and environmental (G x E) determinants of the metabolic syndrome (MetS) in recent immigrants in Europe by a novel approach integrating ancestry of Mediterranean populations in epidemiology, locus refining and Genome Wide Association Studies (GWAS). West ... |
DEXLIFE -
Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression.
Scientific coordinator:
John
Nolan
()
Period: 2012-01-01 - 2015-06-30
Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of ... |
