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IMPROVE - Improving Prostate Cancer Outcome with Vectored Vaccines
Scientific coordinator: Adrian Vivian Hill ()
Period: 2014-04-01 - 2018-03-31
A successful vaccine against cancer is most likely to work through the induction of potent CD8+ T cells that can successfully kill tumour cells. But achieving this has proved difficult and only low level responses are induced by current vaccine approaches. Nonetheless, two therapeutic immunisation ...
ESMART - Randomised controlled trial to evaluate electronic Symptom Management using the Advanced Symptom Management System (ASyMS) Remote Technology for patients with cancers
Scientific coordinator: Nora Kearney ()
Period: 2014-02-01 - 2019-01-31
The eSMART programme of work will demonstrate the effects of a real-time, mobile phone based, remote patient monitoring intervention on key patient outcomes and delivery of care provided to people with cancer during and after chemotherapy. Utilising the remote patient monitoring system, the ...
DISCHARGE - Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies
Scientific coordinator: Marc Dewey ()
Period: 2014-02-01 - 2019-01-31
Coronary artery disease (CAD) is the leading cause of death in high-income countries. Invasive coronary angiography (ICA) is the reference standard for the diagnosis of CAD and allows immediate therapy. However, only 40% of patients undergoing ICA actually have obstructive CAD and ICA has ...
SYSVASC - Systems Biology to Identify Molecular Targets for Vascular Disease Treatment
Scientific coordinator: Burkert Pieske ()
Period: 2014-02-01 - 2018-01-31
Asymptomatic vascular damage accumulates for years before patients are identified and subjected to therapeutic measures. The limited knowledge on early vascular disease pathophysiology is reflected in the lack of therapeutic options. SysVasc aims to overcome this limitation by mounting a ...
ATECT - Advanced T-cell Engineered for Cancer Therapy
Scientific coordinator: Martin Pule ()
Period: 2013-12-01 - 2018-11-30
T-cell engineering strategies for Cancer therapy, either Chimeric Antigen Receptors (CARs) or TCR transfer holds promise to revolutionize cancer treatment. There are, however, considerable barriers to be overcome to take this form of therapy to a format that can benefit all EU citizens with a wide ...
ACTION - Advance Care Planning; an Innovative Palliative Care Intervention to Improve Quality of Life in Cancer Patients - a Multi-Centre Cluster Randomized Clinical Trial
Scientific coordinator: Agnes Van Der Heide ()
Period: 2013-12-01 - 2018-11-30
Advanced cancer typically involves multiple symptoms and seriously affects patients´ quality of life. Anxiety and depression are common. Medical care for patients with advanced cancer should be aimed at symptom control, psychosocial support, spiritual needs, and practical issues. Patients’ ...
MERCURIC - A Phase Ib/II study of MEK1/2 inhibitor PD-0325901 with cMET inhibitor PF-02341066 in KRASMT and KRASWT (with aberrant c-MET) Colorectal Cancer Patients.
Scientific coordinator: Sandra Van Schaeybroeck ()
Period: 2013-12-01 - 2020-11-30
Colorectal cancer (CRC) is the 3rd most common cancer in Europe, and with approximately 200,000 deaths per year, it remains the 2nd most common cause of cancer death. More than half of all CRC patients develop distant metastases and have 5-year overall survival (OS) of less than 5% because of ...
PANCARELIFE - PanCare Studies in Fertility and Ototoxicity to Improve Quality of Life after Cancer during Childhood, Adolescence and Young Adulthood
Scientific coordinator: Peter Kaatsch ()
Period: 2013-11-01 - 2018-10-31
Survival rates after childhood cancer now reach nearly 80% in developed European countries as a result of more effective therapies and better supportive care, leading to a steady increase in the number of survivors in the population. However, the treatments that have improved survival are harsh and ...
IACT - Immunostimulatory Agonist antibodies for Cancer Therapy
Scientific coordinator: Rienk Offringa ()
Period: 2013-11-01 - 2017-10-31
This concerted action aims at providing new treatment options for cancer patients through boosting innovative drug development by European academia and industry. A wealth of preclinical data shows that the therapeutic impact of cytotoxic regimens is enhanced by simultaneous application of drugs ...
CVGENES-AT-TARGET - Exploitation of genomic variants affecting coronary artery disease and stroke risk for therapeutic intervention
Scientific coordinator: Heribert Schunkert ()
Period: 2013-10-01 - 2016-09-30
Atherosclerosis and its most disabling sequelae, coronary artery disease (CAD) and stroke, are leading causes of death in Europe. Until now, preventive and therapeutic interventions for these diseases aim at ameliorating the effects of established cardiovascular risk factors. More recently, results ...
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Last updated on 2014-06-23 at 09:40