Overview
LIVER IVM AND HBV - Imaging liver immunopathology by intravital microscopy (IVM): a new approach to study the pathogenesis of hepatitis B virus (HBV) infection. 

Time period:
2010-09-01 - 2015-08-31
Instrument:
Support for frontier research (ERC)
Call:
ERC Advanced Investigators Grant

Overall objective and Specific Aims. The overall objective of this proposal is to elucidate the pathogenesis of HBV infection with the ultimate hope that this knowledge will lead to the development of new therapeutic strategies to terminate persistent infection and its attendant costs and complications. Our approach is to dissect poorly understood cellular and molecular pathways responsible for both liver disease and viral clearance taking advantage of technological advances in the field of live imaging and unique mouse models of HBV infection. Three specific aims will be pursued: 1. Visualize and characterize where and how naïve and effector CTL of different specificities adhere to vessels and recognize/kill HBV-expressing hepatocytes within the “normal”, fibrotic/cirrhotic or cancerous liver. 2. Characterize the role of platelets in HBV pathogenesis. 3. Characterize the role of Kupffer cells in HBV pathogenesis.

Principal investigators
Scientific co-ordinator:
Maria Rosa Pedrazzi (Ospedale San Raffaele)
Other principal investigators:


Related Areas

Countries
Italy
Last updated on 2014-06-17 at 16:13